2013: Parallel multisite long-term optical dynamic brain interrogation in freely moving mice

Physicists from Moscow State Univ. in collaboration with researchers from T8 NTS and Corning Inc. reached the record 500 km unrepeatered 100 GB/s transmission.

Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meeting this challenge, implantable fiber-optic interfaces integrating advanced optogenetic technologies and cutting-edge fiber-optic solutions have been demonstrated, enabling a long-term optogenetic manipulation of neural circuits in freely moving mice. Here, we show that a specifically designed implantable fiber-optic interface provides a powerful tool for parallel long-term optical interrogation of distinctly separate, functionally different sites in the brain of freely moving mice. This interface allows the same groups of neurons lying deeply in the brain of a freely behaving mouse to be reproducibly accessed and optically interrogated over many weeks, providing a long-term dynamic detection of genome activity in response to a broad variety of pharmacological and physiological stimuli.

The results of this work have been published in (1) Doronina-Amitonova L.V., Fedotov I.V., Ivashkina O.I., Zots M.A., Fedotov A.B., Anokhin K.V., Zheltikov A.M., "Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice", Scientific reports, 3, (2013).; (2) Doronina-Amitonova L.V., Fedotov I.V., Fedotov A.B., Zheltikov A.M., "High-resolution wide-field Raman imaging through a fiber bundle", Applied Physics Letters, 102, 161113 (2013).